Place a large terra cotta pot, about two feet in diameter, on a matching flood tray. Fill the pot about halfway with sand. This will help with fast drainage; night-blooming Cereuses do not like wet feet.
Fill the rest of the pot with potting soil up to about two inches below the pot's lip. Do not pack down the soil; loose soil helps the roots sprout and establish themselves more quickly.
Dig a hole about four inches deep and wide with a trowel in the center of the soil. Drop in a Cereus seed and cover it with soil, packing it down lightly. Water the soil until moist, but not damp, and empty the flood tray immediately. Wait until the soil is dry before watering again.
Place the pot in a sunny window where it gets direct sunlight. Once the plant begins to sprout, move it about three feet from the window so it gets bright but indirect light. This helps prevent burns on the leaves.
Feed the plant with 20-20-20 (equal parts potassium, nitrogen and other vitamins) when it grows to about five inches tall. This will help it to grow more rapidly. When the plant reaches about seven inches, drive a stake into the soil and tie the plant to it gently to aid vertical growth.