Clip a two- to four-inch section of stem from an established night blooming cereus.
Place the cutting in an area out of direct sunlight for two to three days. Allow the end to dry out. This will minimize the risk of diseases and rot when you plant the cutting.
Fill a flowerpot (four to six inches in diameter) with a porous, sandy potting soil. Add perlite or vermiculite to promote drainage. Dig a hole approximately two inches deep. Place the dry end of the cutting into the hole and tamp the soil around it.
Water the potted cutting thoroughly but do not allow the soil to become soggy.
Place the plant in a shady location until the root system develops. It will root within three to six weeks. Water it when the soil dries out.
Provide the night blooming cereus with vertical support as it grows, such as a stake. Night blooming cereus is a vine plant that climbs. It has a slow growth rate, and will grow to approximately three feet within a few years.