Wear a pair of gloves while handling the cactus. The San Pedro doesn't have huge spines, but there are enough to make you very uncomfortable. Hold the cactus at one end and use the knife to pare off the skin at the high points around the circumference where the spines are.
Slice the limb into discs of 1/2 to 1 inch thick. To remove the pith where the mescaline is, cut the limb in half lengthwise and core out the center. You can use a knife or a serrated grapefruit spoon. After the pith is removed, cut the limb into slices.
Lay the discs out on the perforated pan individually. Don't allow them to overlap. Place the tray in the sun for a day or two or until the remaining strips of skin start to curl and roll up. Pull off the skin to enhance drying.
Flip the cactus over and allow it to dry for another two days. Check the center for moisture. The discs can take up to six days to dry.
Store the dried discs in sealed plastic bags in a dark, dry area. Alternatively, use a mortar and pestle to crush the San Pedro cactus and prepare it for tea. Store it in closed glass jars and use it dissolved in water, juice or any other liquid.