Obtain a 3- to 4-inch cutting from a San Pedro cactus.
Allow the cutting to dry for about two weeks in a cool, dry place, like in the shade. This keeps the cutting from getting moldy.
Dip the cutting in rooting hormone.
Plant the cutting in a good mix of topsoil that contains perlite. About half of the cutting should be visible above the soil line. Water the cutting well.
Keep the cutting away from direct sunlight so it doesn't grow too thin. After about six months, the cutting should have developed sufficient roots to allow for re-potting.