Set a layer of stones at the bottom of a 10- to 15-gallon container for proper water draining. Place it in an area of your home, such as an atrium that receives six to eight hours of full sunlight.
Fill the container with an airy perlite potting soil. Use enough soil so that the hole where you plant the sapling is of equal depth and twice as wide as the mulberry tree's root ball. Ensure there is enough soil around the sides of the interior of the pot so the tree experiences increased water absorption.
Place the sapling into the hole and refill it with soil. Do not pack the soil down on the sapling too harshly. Water the soil to collapse any air pockets.
Water the mulberry once a week using 5 gallons of water. Feed the plant once in the early spring and a second time in late summer with 1 lb. of 10-10-10 NPK fertilizer per inch of the tree's trunk diameter. Water before and after fertilizing to prevent root burn.
Cut dying branches with pruning shears as close to the base of the tree as you can. This allows the mulberry tree to focus its energy on producing fruit and foliage.