Remove all bedding including the dust ruffle and mattress pad.
Vacuum the top and side mattress surfaces with the vacuum hose and upholstery attachment. This will remove all loose dirt and dust from the mattress. Turn the mattress over and vacuum the other side as well.
Treat any stained areas with a detergent rub. To make the rub combine 1 tbsp. laundry detergent with 1 cup warm water. Whisk rapidly with a wire whisk until solution is very foamy and bubbly on top. Scoop foam from the top of the solution with a slightly damp, clean rag and rub into the stain in a small circular pattern. When stain has disappeared, blot area with a slightly damp, clean rag to remove remaining suds. Dry the area by blotting with a dry towel.
Allow the mattress to dry thoroughly before replacing the bedding.