EPO is a glycoprotein hormone that is composed of 166 amino acids. It is produced by the interstitial cells of the kidneys, which are located in the outermost layer of the kidney cortex.
EPO is released into the bloodstream in response to hypoxia, which is a condition in which the body's tissues are not receiving enough oxygen. Hypoxia can be caused by a number of factors, including anemia, chronic kidney disease, and high altitude.
When EPO is released into the bloodstream, it binds to receptors on the surface of red blood cell precursors in the bone marrow. This binding stimulates the precursors to differentiate into mature red blood cells.
EPO is essential for the production of red blood cells and for the maintenance of a healthy oxygen supply to the body's tissues.
Here are some of the things that can affect EPO levels:
* Anemia: Anemia is a condition in which the body does not have enough red blood cells. This can lead to hypoxia and increased EPO production.
* Chronic kidney disease: Chronic kidney disease can damage the kidneys' ability to produce EPO. This can lead to anemia and increased EPO production.
* High altitude: High altitude can cause hypoxia and increased EPO production.
* Medications: Some medications, such as corticosteroids and cyclosporine, can decrease EPO production.
* Cancer: Some types of cancer, such as multiple myeloma and leukemia, can produce EPO. This can lead to high EPO levels and polycythemia, which is a condition in which the body has too many red blood cells.
EPO levels are typically measured in units per liter (U/L). The normal range for EPO levels is 5-30 U/L. EPO levels that are higher or lower than this range may indicate a medical condition.
If you have any concerns about your EPO levels, talk to your doctor.