Sterilize pruning shears with a 1 part bleach and 9 parts water solution. This minimizes the risk of spreading disease that they might be harboring from previous tasks in the garden. You can also use a disinfectant spray or a solution made with equal parts water and rubbing alcohol.
Trim evergreen lantana stems up to one-third of their total height. Prune as desired to shape. You can also remove wayward, weak and damaged stems. Cut the stems sharply just above a branch union. Pruning branches just above outward-facing stems creates a fuller look.
Cut back a herbaceous perennial lantana 6 to 12 inches from the ground. Ensure you perform this task after the last spring frost. New growth will quickly sprout to form an informal hedge.