Sterilize your pruning shears with rubbing alcohol before you begin and between each cut. This will prevent the spread of disease.
Prune the bushes in the early spring. Cut the top blackberry canes down to 2 feet or less. Cut the top 1-inch tips off shorter canes.
Prune the blackberry bushes again in the summer. Prune them after the bush stops producing fruit. Remove all canes that produced fruit for the year at the base of the bush to encourage the bush to grow new canes.
Remove diseased and dead canes from the base of the bush. Do this during the spring and summer to prevent diseases from spreading.