Take off the flashing on the outside using a screw gun and pry bar, then go inside the home and remove any molding with the pry bar and claw hammer. Set the flashing and molding aside to reinstall around the new window.
Cut along the outside edges of the window on the exterior side with a utility knife, freeing the glass pane fixture from the caulk.
Unfasten any screws around the exterior of the window, if applicable, using the screw gun. Go back inside, open the window and unfasten any screws in the frame.
Insert the pry bar between the aluminum window frame and the wall, then pry it as loose as possible. Push the window through the opening to the outside once free.
Set the new aluminum picture window in the opening in the wall and fasten the frame to the wall with a screw gun and stainless steel screws. Place wood shims between the window frame and rough opening to fill any gaps, if necessary.
Spread a bead of caulk around both the inside and outside edges of the window to seal it tightly using silicone caulk and a caulk gun.
Reattach the flashing on the outside using more stainless steel screws and a screw gun, then replace the molding on the inside using finishing nails and a hammer to finish the window replacement.